
Enfamil® Optimum™
Our closest ever formula to breast milk. It is the only leading brand with lactoferrin*, a component of breast milk, and has our exclusive HuMO6 Premium Immune Blend† that includes Dual HMOs (2'FL & LNnT).
Enfamil Optimum is a 20 Cal/fl oz milk-based, iron-fortified, routine formula for full-term infants 0–12 months. Enfamil Optimum has lactoferrin* previously only largely available in breast milk to support immune health. It also has naturally occurring MFGM‡, a building block of the brain, as well as expert recommended, brain-building DHA and a dual HMO blend of 2’-FL and LNnT† to support immune and gut health.
*Added as an ingredient
†2’-FL & LNnT HMO (2’-Fucosyllactose & Lacto-N-neotetraose Human Milk Oligosaccharide. Not from human milk), Vit C & E, Selenium, Zinc
‡From whey protein concentrate
Lactoferrin*, an important immune-supporting protein also found in breast milk, has been shown to:
- Supports respiratory and gut health1†
DHA has been demonstrated in clinical studies to:
- Support cognitive and visual development2-5‡
- Promote long-term outcomes through 5 years of age5‡
Brain Building naturally occurring MFGM demonstrated in clinical studies to:
- Provide cognitive development similar to breastfed babies at 12 months of age6
- Increase neurodevelopmental scores at 12 months of age7§
- Support cognitive, motor and communications skills through 5 years of age5,7,8||
A proprietary HuMO6¶ Premium Immune Blend that has 2’-FL and LNnT to support immune and gut health.
Additional Product Features:
- Easy-to-digest 65:35 whey-to-casein ratio, patterned after mature breast milk9♠
- Inositol also found in breast milk♥
- Non-GMO♦
- Kosher Dairy (OU-D), Halal
*Added as an ingredient
†Based on infants who received a LF-supplemented formula between 4-6 months of age
‡Studies compared infants fed Enfamil® that had DHA and ARA vs. discontinued Enfamil without DHA and ARA; studied before the addition of prebiotics.
§As indicated by Bayley-III cognitive, language and motor scores at 12 months in a study of a different formula with MFGM and lactoferrin added as ingredients compared to a standard formula without.
||Cognitive skills as indicated by WPPSI-IV, tested at 5.5 to 6 years of age in a study of infant formula with MFGM. Communication skills as indicated by PPVT-III and WPPSI-III tested at 5 and 6 years of age respectively in a study of infant formula with DHA. Motor skills measured through 12 months of age.
¶2’-FL & LNnT HMO (2’-Fucosyllactose & Lacto-N-neotetraose Human Milk Oligosaccharide. Not from human milk), Vit C & E, Selenium, Zinc
#From whey protein concentrate
♠Comparison based on whey:casein ratio of typical mature breast milk (15 days to 6 months after birth)8
♥The global average total inositol amount in mature breast milk over the course of lactation is 22 mg/100 kcal.
♦Ingredients not genetically engineered. Trace amounts of genetically engineered material may be presented in the product, such as from manufacturing environments and process sources. For more information, visit enfamil.com/nonGMO ↗
Enfamil Optimum is designed to provide the sole source of nutrition for infants up to age 6 months and provide a major source of nutrition for the remainder of the first year.
Ingredients - Powder: Nonfat milk, lactose, vegetable oil (contains one or more of the following: palm olein oil, coconut oil, soy oil, high oleic sunflower oil), whey protein concentrate*, and less than 2%: Lacto-N-neotetraose†, 2’-Fucosyllactose†, lactoferrin, Mortierella alpina oil‡, Schizochytrium sp. oil§, calcium carbonate, calcium phosphate, cupric sulfate, ferrous sulfate, magnesium oxide, manganese sulfate, potassium chloride, potassium citrate, potassium iodide, sodium chloride, sodium selenite, zinc sulfate, soy lecithin, choline chloride, inositol, ascorbic acid, biotin, calcium pantothenate, folic acid, niacinamide, riboflavin, thiamin hydrochloride, vitamin B12, vitamin B6 hydrochloride, vitamin D3, vitamin K1, vitamin E acetate, vitamin A palmitate, taurine, L-carnitine.
*A source of MFGM (milk fat globule membrane).
†A source of HMO (2’-fl & LNnT human milk oligosaccharides)
‡A source of arachidonic acid (ARA)
§A source of docosahexaenoic acid (DHA)
Potential Allergens
Enfamil Optimum contains milk and soy.
Ingredient Transparency
Explore the function behind our ingredients.
| Nutrients (Normal Dilution) | Per 100 Calories (5 fl oz) | Per 100 mL | Per Quart | Per 100 g Powder |
|---|---|---|---|---|
| Protein, g (% of total cal) | 2.1 (8.5%) | 1.42 | 13.4 | 10.8 |
| Fat, g (% of total cal) | 5.3 (48%) | 3.6 | 34 | 27 |
| Carbohydrate, g (% of total cal) | 11.1 (43.5%) | 7.5 | 71 | 57 |
| Calories | 100 | 68 | 640 | 510 |
| Water, g | 133 | 90 | 850 | 2.4 |
| Linoleic Acid, mg | 780 | 530 | 5000 | 4000 |
| Linolenic Acid, mg* | 72 | 49 | 460 | 370 |
| Arachidonic Acid, mg* | 25 | 16.9 | 160 | 129 |
| Docosahexaenoic Acid, mg* | 17 | 11.5 | 109 | 87 |
| Vitamin A, IU | 300 | 200 | 1920 | 1540 |
| Vitamin D, IU | 70 | 47 | 450 | 360 |
| Vitamin E, IU | 2 | 1.35 | 12.8 | 10.3 |
| Vitamin K, mcg | 9 | 6.1 | 58 | 46 |
| Thiamin (Vitamin B1), mcg | 80 | 54 | 510 | 410 |
| Riboflavin (Vitamin B2), mcg | 140 | 95 | 900 | 720 |
| Vitamin B6, mcg | 60 | 41 | 380 | 310 |
| Vitamin B12, mcg | 0.3 | 0.2 | 1.92 | 1.54 |
| Niacin, mcg | 1000 | 680 | 6400 | 5100 |
| Folic Acid (folacin), mcg | 16 | 10.8 | 102 | 82 |
| Pantothenic Acid, mcg | 500 | 340 | 3200 | 2600 |
| Biotin, mcg | 3 | 2 | 19.2 | 15.4 |
| Vitamin C (Ascorbic Acid), mg | 12 | 8.1 | 77 | 62 |
| Choline, mg | 24 | 16.2 | 154 | 123 |
| Inositol, mg | 24 | 16.2 | 154 | 122 |
| L-Carnitine, mg* | 2 | 1.35 | 12.8 | 10.3 |
| Taurine, mg* | 6 | 4.1 | 38 | 31 |
| Calcium, mg | 78 | 53 | 500 | 400 |
| Phosphorus, mg | 43 | 29 | 280 | 220 |
| Magnesium, mg | 8 | 5.4 | 51 | 41 |
| Iron, mg | 1.8 | 1.22 | 11.5 | 9.3 |
| Zinc, mg | 1 | 0.68 | 6.4 | 5.1 |
| Manganese, mcg | 15 | 10.1 | 96 | 77 |
| Copper, mcg | 75 | 51 | 480 | 390 |
| Iodine, mcg | 15 | 10.1 | 96 | 77 |
| Selenium, mcg | 2.8 | 1.89 | 17.9 | 14.4 |
| Sodium, mg | 27 | 18.3 | 173 | 139 |
| Potassium, mg | 108 | 73 | 690 | 560 |
| Chloride, mg | 63 | 43 | 400 | 320 |
Product nutrient values and ingredients are subject to change. Please see product label for current information.
Nutrient Facts
| Nutrient Density | 20 Calories/fl oz |
|---|---|
| Protein (% Calories) | 8.5 |
| Whey:Casein Ratio | 65:35 |
| Fat (% Calories) | 48 |
| Carbohydrate (% Calories) | 43.5 |
| Potential Renal Solute Load (mOsm/100 Calories)1 | 19.1 |
| Potential Renal Solute Load (mOsm/100 mL)1 | 12.9 |
| Osmolality (mOsm/kg water) | 300 |
| Osmolarity (mOsm/L) | 270 |
| Lactose-free | No |
1. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14.
DILUTION INFORMATION FOR ENFAMIL OPTIMUM
Mixing instructions by the scoop
Download dilution information ↗
Mixing instructions by the quart
Download dilution information ↗
POWDER
A baby’s health depends on carefully following the instructions below. Use only as directed by a medical professional. Proper hygiene, preparation, dilution, use, and storage are important when preparing infant formula. Powdered infant formulas are not sterile and should NOT be fed to premature infants or infants who might have immune problems unless directed and supervised by a doctor.
Discuss with parents which formula is appropriate for the baby.
Discuss with parents whether they need to use cooled, boiled water for mixing and whether they need to boil clean utensils, bottles, and nipples in water before use.
WARNING: Do not use a microwave oven to warm formula. Serious burns may result.
Refer to the product label for the most accurate information.
Failure to follow these instructions could result in severe harm. Once prepared, infant formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use prepared formula if it is unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use formula within 1 hour or discard.
- Wash hands thoroughly with soap and water before preparing formula.
- Pour the desired amount of water into the bottle. Add powder.
- Cap bottle and SHAKE WELL.
Use the following chart for correct amounts of water and powder.
| To Make* | Water | Powder | Weight |
|---|---|---|---|
| 2 fl oz bottle | 2 fl oz | 1 unpacked level scoop* | 8.8 g |
| 4 fl oz bottle | 4 fl oz | 2 unpacked level scoops* | 17.6 g |
| 8 fl oz bottle | 8 fl oz | 4 unpacked level scoops* | 35.2 g |
*Each scoop adds about 0.2 fl oz to the amount of prepared formula.
POWDER STORAGE
Tubs
Store powder at room temperature; avoid extreme temperatures. After opening, keep pouch and tub lid tightly closed, store in a dry area and use contents within 1 month. Use tub with formula indicated on label only.
Keep powder fresh and prevent bacterial growth by assuring tub is clean and completely dry. When using refill pouches, remove the empty pouch and wipe tub with a clean, dry cloth. When using refill pouches, remove the empty pouch and wipe tub with a clean, dry cloth.
Caution
- ALWAYS REFER TO THE BATCH CODE AND "USE BY" DATE ON THE REFILL POUCH.
Cans
Store cans at room temperature. After opening can, keep tightly covered,
store in dry area and use contents within 1 month. Do not freeze powder
and avoid excessive heat.
Caution
- USE BY DATE ON BOTTOM OF CAN
READY-TO-USE
A baby’s health depends on carefully following the instructions below. Use as directed by a medical professional. Proper hygiene, preparation, use, and storage are important when preparing infant formula. Discuss with parents which formula is appropriate for the baby. Discuss with parents whether they need to boil a clean nipple in water before use.
32 FL OZ BOTTLES
- Wash hands thoroughly with soap and water before preparing feeding bottles.
- SHAKE BOTTLE WELL, remove protective seal around cap, remove cap and foil seal. Replace cap.
- Pour into feeding bottle(s).
WARNING: Do not use a microwave oven to warm formula. Serious burns may result.
Failure to follow these instructions could result in severe harm. Opened bottles and prepared formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 48 hours. Do not use opened bottle and/or prepared formula if they are unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use prepared formula within 1 hour or discard.
READY-TO-USE STORAGE
32 fl oz Bottles
Store unopened bottles at room temperature. Avoid excessive heat. Do not freeze.
Caution
- DO NOT ACCEPT IF PACKAGE HAS BEEN OPENED
- DO NOT USE IF PROTECTIVE SEAL AROUND CAP, OR IF FOIL SEAL UNDER CAP,
- USE BY DATE ON SIDE OF BOTTLE
ENFAMIL OPTIMUM IS AVAILABLE IN POWDER
Coding systems and reimbursement allowable rates vary by payer:
- Medicare Part B uses HCPCS (Healthcare Common Procedure Coding System) to group products
- Medicaid systems vary by state; some use HCPCS while others use NDC format code or systems of their own—contact your state provider for more information
- Private health insurance and managed care companies may use HCPCS, NDC format code or their own system—contact your provider for more information

Enfamil® Optimum™, Powder (20.5 oz tub)
Item #: 157401
Description: Powder
Unit Size: 20.5 oz tub
Calories/Unit: 2920
Product Yield/Unit (fl oz): 146
Case: 4 tubs per case
HCPCS Code: B4158
NDC Format Code: 00087-5117-48

Enfamil® Optimum™, Powder (30 oz Refill)
Item #: 157401
Description: Powder
Unit Size: 20.5 oz tub
Calories/Unit: 2920
Product Yield/Unit (fl oz): 146
Case: 4 tubs per case
HCPCS Code: B4158
NDC Format Code: 00087-5117-48

Enfamil® Optimum™, Powder (27.4oz can)
Item #: 195304
Description: Powder
Unit Size: 27.4 oz tub
Calories/Unit: 3920
Product Yield/Unit (fl oz): 196
Case: 4 cans per case
HCPCS Code: B4158*
NDC Format Code: 00087-5126-82

Enfamil® Optimum™, Ready-To-Feed (32 fl oz bottle)
Item #: 3310310
Description: RTF
Unit Size: 32 fl oz bottle
Calories/Unit: 640
Product Yield/Unit (fl oz): 32
Case: 6 bottles per case
HCPCS Code: B4158
NDC Format Code: 00087-5126-82

Enfamil® Gentlease®
More Information

Enfamil® NeuroPro™ Infant
Infant formula brand that has expert-recommended brain-building DHA, naturally occurring MFGM components* and a proprietary HuMO6™† immune blend including PDX, GOS, and 2′-FL HMO‡
More Information
Clinical Monograph
NEW INSIGHTS INTO BIOACTIVE COMPONENTS OF HUMAN MILK: LACTOFERRIN
Clinical Monograph
NEW INSIGHTS INTO PEDIATRIC NUTRITION: MILK FAT GLOBULE MEMBRANE
Clinical Study
- Chen K, Chia L, Li H, et al. Effect of bovine lactoferrin from iron-fortified formulas on diarrhea and respiratory tract infections of weaned infants in a randomized controlled trial. Nutrition. 2016;32:222-227.
- Birch EE, Hoffman DR, Uauy R, et al. Visual acuity and the essentiality of docosahexaenoic acid and arachidonic acid in the diet of term infants. Pediatr Res. 1998;44:201-209.
- Birch EE, Garfield S, Hoffman DR, et al. A randomized controlled trial of early dietary supply of long-chain polyunsaturated fatty acids and mental development in term infants. Dev Med Child Neurol. 2000;42:174-181.
- Morale SE, Hoffman DR, Castaneda YS, et al. Duration of long-chain polyunsaturated fatty acids availability in the diet and visual acuity. Early Hum Dev. 2005;81:197-203.
- Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation on childhood cognitive outcomes. Am J Clin Nutr. 2013;98:403-412.
- Timby N, Domellöf E, Hernell O, Lönnerdal B, Domellöf M. Neurodevelopment, nutrition, and growth until 12 mo of age in infants fed a low-energy, low-protein formula supplemented with bovine milk fat globule membranes: a randomized controlled trial. Am J Clin Nutr. 2014;99(4):860-868.
- Li F, Wu SS, Berseth CL, et al. Improved Neurodevelopmental Outcomes Associated with Bovine Milk Fat Globule Membrane and Lactoferrin in Infant Formula: A Randomized, Controlled Trial. J Pediatr. 2019;215:24-31.e8.
- Colombo J, Harris CL, Wampler JL, et al. Improved Neurodevelopmental Outcomes at 5.5 Years of Age in Children Who Received Bovine Milk Fat Globule Membrane and Lactoferrin in Infant Formula Through 12 Months: A Randomized Controlled Trial [published online ahead of print, 2023 May 14]. J Pediatr. 2023;261:113483. doi:10.1016/j.jpeds.2023.113483
- Kunz C, Lönnerdal B. Re-evaluation of the whey protein/casein ratio of human milk.