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Enfamil® NeuroPro® Gentlease®
Milk-based formula designed to help ease fussiness, crying, gas, and spit-up within 24 hours1 and promote soft stools. It has expert-recommended brain-building DHA, naturally occurring MFGM components* and a proprietary HuMO6™† immune blend and gentle blend including 2′-FL HMO.‡ And a patented dual prebiotic blend of PDX and GOS.
Enfamil NeuroPro Gentlease is a 20 Cal/fl oz, milk-based infant formula designed to ease fussiness, crying, gas and spit-up1 and promote soft stools. It has easy-to-digest gentle partially hydrolyzed proteins for digestive comfort as well as 80% less lactose than standard routine formulas. Enfamil NeuroPro Gentlease has expert-recommended brain-building DHA, naturally occurring MFGM components* and is the only gentle brand that has a proprietary blend of PDX and GOS as well as 2’-FL HMO.‡
*From whey protein concentrate.
†2’-FL HMO, Vit C & E, Selenium, partially hydrolyzed protein, reduced lactose.
‡2’-Fucosyllactose Human Milk Oligosaccharide. Not from human milk.
Designed to have easy-to-digest gentle partially hydrolyzed to support digestive comfort
- All-in-one gentle comfort for easing fussiness, crying, gas, and spit-up in 24 hours1*
- 80% reduced lactose compared to standard routine formulas
- Easy-to-digest 60:40 whey-to-casein ratio prior to partial hydrolyzation, patterned after mature breast milk†
- Safe and well-tolerated source of nutrition
DHA has been demonstrated in clinical studies to:
- Support cognitive and visual development2-5‡
- Promote long-term cognitive outcomes through 5 years of age5‡
Brain Building naturally occurring MFGM components demonstrated in clinical studies to:
- Provide cognitive development similar to breastfed babies at 12 months of age6
- Increase neurodevelopmental scores at 12 months of age7§
- Support cognitive, motor, and communication skills through 5 years of age8||
A proprietary HuMO6™§ immune and gentle blend including 2’-FL HMO and a patented dual prebiotic blend of GOS and PDX, designed to support a baby’s immune and gut health:
- Infant formula that has a combination of GOS and PDX has been shown to support immune health by promoting the growth of beneficial bacteria (bifidobacteria and lactobacilli)9-10
- Infant formula that has a combination of GOS and PDX has been shown to promote soft stools similar to those reported for breastfed infants11
- Infant formula that has a combination of GOS and 2’-FL HMO has been associated with a 66% reduction in respiratory infections, based on a parental report in a post-hoc analysis.12
- Infant formula that has partially hydrolyzed protein and a combination of GOS and PDX has been shown to promote softer, more frequent stools within 1 week in infants with difficult stooling.13§
Additional product features:
- Non-GMO#
- Kosher Dairy (OU-D), Halal
- Inositol at the average amount found in breast milk♠
*Study conducted prior to the addition of PDX, GOS, and milk fat globule membrane (MFGM) in the Gentlease® formula. Among infants identified as very or extremely fussy by parent report receiving a full-lactose cow’s milk protein formula for 7 days prior to enrollment, as compared with baseline.
†Comparison based on whey:casein ratio of typical mature breast milk (15 days to 6 months after birth).14
‡Studies compared infants fed Enfamil® that had DHA and ARA vs. discontinued Enfamil without DHA and ARA; studied before the addition of prebiotics.
§As indicated by Bayley-III cognitive, language and motor scores at 12 months in a study of a different formula with MFGM and lactoferrin added as ingredients compared to a standard formula without.
||As indicated by WPPSI-IV, tested at 5.5-6 years of age
¶Compared with a non-hydrolyzed formula that had PDX and GOS.
#Ingredients not genetically engineered. Trace amounts of genetically engineered material may be present in the product, such as from manufacturing environments and process sources. For more information, visit enfamil.com/nonGMO ↗.
♠The global average total inositol level in mature breast milk over the course of lactation is 22 mg/100 kcal.
Enfamil NeuroPro Gentlease is designed to provide the sole source of nutrition for infants up to age 6 months and provide a major source of nutrition for the remainder of the first year.
Ingredients - Powder:Corn syrup solids, partially hydrolyzed nonfat milk and whey protein concentrate solids (soy)*, vegetable oil (palm olein, coconut, soy and high oleic sunflower oils), and less than 2%: 2’-Fucosyllactose†, galactooligosaccharides‡, polydextrose‡, Mortierella alpina oil §, Schizochytrium sp. oil ||, calcium carbonate, sodium citrate, calcium phosphate, potassium chloride, magnesium phosphate, ferrous sulfate, zinc sulfate, cupric sulfate, manganese sulfate, potassium iodide, sodium selenite, choline chloride, inositol, ascorbic acid, niacinamide, calcium pantothenate, riboflavin, thiamin hydrochloride, vitamin D3, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin B12, vitamin E acetate, vitamin A palmitate, soy lecithin, taurine, L-carnitine.
Ingredients – Ready to Drink:Water, corn syrup solids, partially hydrolyzed nonfat milk and whey protein concentrate solids (soy)*, vegetable oil (palm olein, soy, coconut, and high oleic sunflower oils), and less than 2%: 2’-Fucosyllactose†, Mortierella alpina oil §, Schizochytrium sp. oil ||, rice starch, calcium phosphate, calcium carbonate, magnesium phosphate, potassium chloride, potassium citrate, sodium chloride, ferrous sulfate, zinc sulfate, cupric sulfate, manganese sulfate, potassium iodide, sodium selenite, ascorbic acid, vitamin E acetate, niacinamide, calcium pantothenate, vitamin A palmitate, riboflavin, thiamin hydrochloride, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin D3, vitamin B12, choline chloride, inositol, soy lecithin, taurine, diacetyl tartaric acid ester of mono- and diglycerides (datem), L-carnitine.
Potential Allergens
Enfamil® NeuroPro® Gentlease® contains milk and soy.
*A source of MFGM (milk fat globule membrane composed of proteins and fats) components.
†A source of 2’-FL HMO (2’-fucosyllactose human milk oligosaccharide).
‡A type of prebiotic.
§A source of arachidonic acid (ARA)
||A source of docosahexaenoic acid (DHA).
Ingredient Transparency
| Nutrients (Normal Dilution) | Per 100 Calories (5 fl oz) | Per 100 mL | Per Quart | Per 100 g Powder |
|---|---|---|---|---|
| Protein, g (% of total cal) | 2.3 (9%) | 1.56 | 14.7 | 11.7 |
| Fat, g (% of total cal) | 5.3 (48%) | 3.6 | 34 | 27 |
| Carbohydrate, g (% of total cal) | 11.1 (43%) | 7.5 | 71 | 57 |
| Calories | 100 | 68 | 640 | 510 |
| Water, g | 133 | 90 | 850 | 2.1 |
| Linoleic Acid, mg | 780 | 530 | 5000 | 4000 |
| Linolenic Acid, mg (not declared on label) | 72 | 49 | 460 | 370 |
| Arachidonic Acid, mg (not declared on label) | 25 | 16.9 | 160 | 128 |
| Docosahexaenoic Acid, mg (not declared on label) | 17 | 11.5 | 109 | 87 |
| Vitamin A, IU | 300 | 200 | 1920 | 1530 |
| Vitamin D, IU (Pwd)* | 70 | 47 | 450 | 360 |
| Vitamin E, IU | 2 | 1.35 | 12.8 | 10.2 |
| Vitamin K, mcg | 9 | 6.1 | 58 | 46 |
| Thiamin (Vitamin B1), mcg | 80 | 54 | 510 | 410 |
| Riboflavin (Vitamin B2), mcg | 140 | 95 | 900 | 710 |
| Vitamin B6, mcg | 60 | 41 | 380 | 310 |
| Vitamin B12, mcg | 0.3 | 0.2 | 1.92 | 1.53 |
| Niacin, mcg | 1000 | 680 | 6400 | 5100 |
| Folic Acid (folacin), mcg | 16 | 10.8 | 102 | 82 |
| Pantothenic Acid, mcg | 500 | 340 | 3200 | 2600 |
| Biotin, mcg | 3 | 2 | 19.2 | 15.3 |
| Vitamin C (Ascorbic Acid), mg | 12 | 8.1 | 77 | 61 |
| Choline, mg | 24 | 16.2 | 154 | 122 |
| Inositol, mg | 24 | 16.2 | 154 | 122 |
| L-Carnitine, mg (not declared on label) | 2 | 1.35 | 12.8 | 10.2 |
| Taurine, mg (not declared on label) | 6 | 4.1 | 38 | 31 |
| Calcium, mg | 82 | 55 | 520 | 420 |
| Phosphorus, mg | 46 | 31 | 290 | 230 |
| Magnesium, mg | 8 | 5.4 | 51 | 41 |
| Iron, mg | 1.8 | 1.22 | 11.5 | 9.2 |
| Zinc, mg | 1 | 0.68 | 6.4 | 5.1 |
| Manganese, mcg | 15 | 10.1 | 96 | 77 |
| Copper, mcg | 75 | 51 | 480 | 380 |
| Iodine, mcg | 15 | 10.1 | 96 | 77 |
| Selenium, mcg | 2.8 | 1.89 | 17.9 | 14.3 |
| Sodium, mg (mEq) | 40 (1.74) | 27 (1.18) | 260 (11.1) | 200 (8.9) |
| Potassium, mg (mEq) | 108 (2.8) | 73 (1.87) | 690 (17.7) | 550 (14.1) |
| Chloride, mg (mEq) | 63 (1.77) | 43 (1.2) | 400 (11.4) | 320 (9.1) |
*Vitamin D levels for ready-to-use are: 65 IU/100cal, 44 IU/100 mL, 420 IU/Quart.
Source of Protein: Partially hydrolyzed nonfat milk and whey protein concentrate
Source of Fat: Palm olein, soy, coconut, high oleic sunflower oils, and single cell oil blend of DHA and ARA
Source of Carbohydrate: Corn syrup solids, lactose, prebiotic blend of PDX and GOS
| Nutrient Density | 20 Calories/fl oz |
|---|---|
| Protein (% Calories) | 9 |
| Fat (% Calories) | 48 |
| Carbohydrate (% Calories) | 43 |
| Potential Renal Solute Load (mOsm/100 Calories)1 | 21 |
| Potential Renal Solute Load (mOsm/100 mL)1 | 14.2 |
| Osmolality (mOsm/kg water) | 210 |
| Osmolarity (mOsm/L) | 189 |
| Lactose-free | No |
DILUTION INFORMATION FOR ENFAMIL NEUROPRO GENTLEASE
Mixing instruction by the scoop
Download dilution information ↗
Mixing instruction by the quart
Download dilution information ↗
POWDER
A baby’s health depends on carefully following the instructions below. Use only as directed by a medical professional. Proper hygiene, preparation, dilution, use, and storage are important when preparing infant formula. Powdered infant formulas are not sterile and should NOT be fed to premature infants or infants who might have immune problems unless directed and supervised by a doctor.
Discuss with parents which formula is appropriate for the baby.
Discuss with parents whether they need to use cooled, boiled water for mixing and whether they need to boil clean utensils, bottles, and nipples in water before use.
WARNING: Do not use a microwave oven to warm formula. Serious burns may result.
Refer to the product label for the most accurate information.
Failure to follow these instructions could result in severe harm. Once prepared, infant formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use prepared formula if it is unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use formula within 1 hour or discard.
- Wash hands thoroughly with soap and water before preparing formula.
- Pour the desired amount of water into the bottle. Add powder.
- Cap bottle and SHAKE WELL.
Use the following chart for correct amounts of water and powder.
| To Make* | Water | Powder | Weight |
|---|---|---|---|
| 2 fl oz bottle | 2 fl oz | 1 unpacked level scoop | 8.74 g |
| 4 fl oz bottle | 4 fl oz | 2 unpacked level scoops | 17.48 g |
| 8 fl oz bottle | 8 fl oz | 4 unpacked level scoops | 34.96 g |
*Each packet adds about 0.4 fl oz to the amount of prepared formula.
POWDER STORAGE
Tubs
Store powder at room temperature; avoid extreme temperatures. After opening, keep lid tightly closed, store in a dry area and use contents within 1 month. Use tub with formula indicated on label only.
Keep powder fresh and prevent bacterial growth by assuring tub is clean and completely dry. Completely empty tub and wipe clean with a clean, dry cloth before refilling.
If you choose to empty the pouch into the tub, you must retain the batch code and “use by” date sticker from the pouch.
Caution
- USE BY DATE ON LABEL OF CURRENT POUCH
Cans
Store cans at room temperature. After opening can, keep tightly covered, store in dry area and use contents within 1 month. Do not freeze powder and avoid excessive heat.
Caution
- USE BY DATE ON BOTTOM OF CAN
SINGLE SERVE PACKETS
Failure to follow these instructions could result in severe harm. Once prepared, infant formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use prepared formula if it is unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use formula within 1 hour or discard.
- Wash hands thoroughly with soap and water before preparing formula.
- Pour desired amount of water into bottle. Pour entire contents of packet(s) into bottle.
- Cap bottle and SHAKE WELL.
WARNING: Do not use a microwave oven to warm formula. Serious burns may result.
Use the chart below for correct amounts of water and powder.
| To Make* | Water | Powder | Weight |
|---|---|---|---|
| 4 fl oz bottle | 4 fl oz | 1 packet | 17.48 g |
| 8 fl oz bottle | 8 fl oz | 2 packets | 34.96 g |
*Each scoop adds about 0.2 fl oz to the amount of prepared formula.
SINGLE SERVE PACKET STORAGE
Store unopened packets at room temperature. Do not freeze powder and avoid excessive heat.
Caution
- USE BY DATE ON PACKET
READY-TO-USE
A baby’s health depends on carefully following the instructions below. Use as directed by a medical professional. Proper hygiene, preparation, use, and storage are important when preparing infant formula. Discuss with parents which formula is appropriate for the baby. Discuss with parents whether they need to boil a clean nipple in water before use.
2 & 6 FL OZ NURSETTE® BOTTLES
- Inspect each bottle for signs of damage.
- Wash hands thoroughly with soap and water before preparing bottle for feeding.
- SHAKE BOTTLE WELL and remove cap.
- Attach nipple unit (not included).
WARNING: Do not use a microwave oven to warm formula. Serious burns may result.
Failure to follow these instructions could result in severe harm. Opened bottles can spoil quickly. Either feed immediately or replace cap and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use opened bottle if it is unrefrigerated for more than a total of 2 hours. Do not freeze. After feeding begins, use formula within 1 hour or discard.
8 FL OZ BOTTLES
- Inspect each bottle for signs of damage.
- Wash hands thoroughly with soap and water before preparing bottle for feeding.
- SHAKE BOTTLE WELL and remove cap.
- Attach nipple unit (not included).
WARNING: Do not use a microwave oven to warm formula. Serious burns may result.
Failure to follow these instructions could result in severe harm. Opened bottles can spoil quickly. Either feed immediately or replace cap and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use opened bottle if it is unrefrigerated for more than a total of 2 hours. Do not freeze. After feeding begins, use formula within 1 hour or discard.
32 FL OZ BOTTLES
- Wash hands thoroughly with soap and water before preparing feeding bottles.
- SHAKE BOTTLE WELL, remove protective seal around cap, remove cap and foil seal. Replace cap.
- Pour into feeding bottle(s).
WARNING: Do not use a microwave oven to warm formula. Serious burns may result.
Failure to follow these instructions could result in severe harm. Opened bottles and prepared formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 48 hours. Do not use opened bottle and/or prepared formula if they are unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use prepared formula within 1 hour or discard.
READY-TO-USE STORAGE
2 & 6 fl oz Nursette® Bottles
Store unopened bottles at room temperature. Avoid excessive heat and prolonged exposure to light. Do not freeze.
Caution
- DO NOT ACCEPT IF PACKAGE HAS BEEN OPENED
- DO NOT USE IF CAP RING IS BROKEN OR MISSING
- USE BY DATE ON CARTON AND BOTTLE LABEL
8 & 32 fl oz Bottles
Store unopened bottles at room temperature. Avoid excessive heat. Do not freeze.
Caution
- DO NOT ACCEPT IF PACKAGE HAS BEEN OPENED
- DO NOT USE IF PROTECTIVE SEAL AROUND CAP, OR IF FOIL SEAL UNDER CAP,
- USE BY DATE ON SIDE OF BOTTLE
ENFAMIL NEUROPRO GENTLEASE IS AVAILABLE IN THE FOLLOWING POWDER AND READY-TO-FEED LIQUID FORMULATIONS
Coding systems and reimbursement allowable rates vary by payer:
- Medicare Part B uses HCPCS (Healthcare Common Procedure Coding System) to group products
- Medicaid systems vary by state; some use HCPCS while others use NDC format code or systems of their own—contact your state provider for more information
- Private health insurance and managed care companies may use HCPCS, NDC format code or their own system—contact your provider for more information
Enfamil® NeuroPro® Gentlease®, Powder (19.5 oz tub)
Item #: 267601
Description: Powder
Unit Size: 19.5 oz tub
Calories/Unit: 2800
Product Yield/Unit (fl oz): 140
Case: 4 tubs per case
HCPCS Code: B4158
NDC Format Code: 00087-5121-19
Enfamil® NeuroPro® Gentlease®, Powder Refill (30.4 oz box)
Item #: 267603
Description: Powder, Refill
Unit Size: 30.4 oz box
Calories/Unit: 4380
Product Yield/Unit (fl oz): 218
Case: 4 boxes per case
HCPCS Code: B4158
NDC Format Code: 00087-5121-23
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Enfamil® NeuroPro®Gentlease®, Powder Refill (35.2 oz box)
Item #: 267604
Description: Powder, Refill
Unit Size: 35.2 oz box
Calories/Unit: 5080
Product Yield/Unit (fl oz): 254
Case: 4 boxes per case
HCPCS Code: B4158
NDC Format Code: 00087-5121-23
Enfamil® NeuroPro® Gentlease®, Powder (27.4 oz can)
Item #: 267607
Description: Powder
Unit Size: 27.4 oz can
Calories/Unit: 3960
Product Yield/Unit (fl oz): 198
Case: 4 cans per case
HCPCS Code: B4158
NDC Format Code: 00087-5121-21
Enfamil® NeuroPro® Gentlease®, Single-Serve Powder Packets
Item #: 267605
Description: Single-Serve Powder Packets
Unit Size: 17.4 g stick packs (14 per carton)
Calories/Unit: 1120
Product Yield/Unit (fl oz): 56
Case: 4 cartons per case
HCPCS Code: B4158
NDC Format Code: 00087-5121-13
Enfamil® NeuroPro® Gentlease®, Ready-to-Feed (2 fl oz Nursette® bottle)
Item #: 898103
Description: RTF
Unit Size: 2 fl oz bottle
Calories/Unit: 40
Product Yield/Unit (fl oz): 2
Case: 48 bottles per case
HCPCS Code: B4158
NDC Format Code: 00087-1464-41
Enfamil® NeuroPro® Gentlease®, Ready-to-Feed (6 fl oz bottle)
Item #: 898001
Description: RTF
Unit Size: 6 fl oz bottle
Calories/Unit: 120
Product Yield/Unit (fl oz): 6
Case: 24 bottles per case
HCPCS Code: B4158
NDC Format Code: 00087-5105-23
Enfamil® NeuroPro® Gentlease®, Ready-to-Feed (32 fl oz bottle)
Item #: 494104
Description: RTF
Unit Size: 32 fl oz bottle
Calories/Unit: 640
Product Yield/Unit (fl oz): 32
Case: 6 bottles per case
HCPCS Code: B4158
NDC Format Code: 00087-5115-62
Enfamil® Optimum™ Gentlease®
Our closest ever gentle formula to breast milk. It is the only leading brand that has lactoferrin*, a component also found in breast milk and has our exclusive HuMO6 Premium Immune Blend† that has Dual HMOs (2'FL & LNnT).
More Information
Enfamil® Reguline®
Milk-based infant formula designed to support gut health and promote soft stools with our exclusive Natural Defense® Dual Prebiotic blend.
More Information
Clinical study
Clinical study
Improved Neurodevelopmental Outcomes at 5.5 Years of Age in Children Who Received Bovine Milk Fat Globule Membrane and Lactoferrin in Infant Formula Through 12 Months: A Randomized Controlled Trial
Clinical study
Clinical study
Clinical study
Clinical study
Clinical study
Enfamil® NeuroPro® Gentlease® Is Women, Infant, and Children (WIC®) Program* Eligible in Some States
*WIC is a registered trademark of the United States Department of Agriculture (USDA) for the Women, Infants, and Children Program. No endorsement of any brand or product by the USDA is implied or intended.
Savings and Support Programs to Share with Parents
Help parents receive supplemental nutrition approved formulas
- Berseth CL, Johnston WH, Stolz Sl, et al. Clinical response to 2 commonly used switch formulas occurs within 1 day. Clin Pediatr (Phila). 2009;48:58-65.
- Birch EE, Hoffman DR, Uauy R, et al. Visual acuity and the essentiality of docosahexaenoic acid and arachidonic acid in the diet of term infants. Pediatr Res. 1998;44:201-209.
- Birch EE, Garfield S, Hoffman DR, et al. A randomized controlled trial of early dietary supply of long-chain polyunsaturated fatty acids and mental development in term infants. Dev Med Child Neurol. 2000;42:174-181.
- Morale SE, Hoffman DR, Castaneda YS, et al. Duration of long-chain polyunsaturated fatty acids availability in the diet and visual acuity. Early Hum Dev. 2005;81:197-203.
- Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation on childhood cognitive outcomes. Am J Clin Nutr. 2013;98:403-412.
- Timby N, Domellöf E, Hernell O, Lönnerdal B, Domellöf M. Neurodevelopment, nutrition, and growth until 12 mo of age in infants fed a low-energy, low-protein formula supplemented with bovine milk fat globule membranes: a randomized controlled trial. Am J Clin Nutr. 2014;99(4):860-868.
- Li F, Wu SS, Berseth CL, et al. Improved neurodevelopmental outcomes associated with bovine milk fat globule membrane and lactoferrin in infant formula: a randomized, controlled trial. J Pediatr. 2019;215:24-31.e8.
- Colombo J, Harris CL, Wampler JL, et al. Improved neurodevelopmental outcomes at 5.5 years of age in children who received bovine milk fat globule membrane and lactoferrin in infant formula through 12 months: a randomized controlled trial [published online ahead of print, 2023 May 14]. J Pediatr. 2023;261:113483. doi:10.1016/j.jpeds.2023.113483
- Scalabrin D, Mitmesser SH, Welling GW, et al. New prebiotic blend of polydextrose and galacto-oligosaccharides has a bifidogenic effect in young infants. J Pediatr Gastroenterol Nutr. 2012;54:343-352.
- Salminen S, Endo A, Isolauri E, et al. Early gut colonization with lactobacilli and staphylococcus in infants: the hygiene hypothesis extended. J Pediatr Gastroenterol Nutr. 2016;62:80-86.
- Ziegler E, Vanderhoof JA, Petschow B, et al. Term infants fed formula supplemented with selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. J Pediatr Gastroenterol Nutr. 2007;44:359-364.
- Reverri EJ, Devitt AA, Kajzer JA, Baggs GE, Borschel MW. Review of the clinical experiences of feeding infants formula containing the human milk oligosaccharide 2’-fucosyllactose. Nutrients. 2018;10(10):1346.
- Fabrizio V, Harris CL, Walsh KR, Wampler JL, Zhuang W, Wu SS. Softer more frequent stools in infants with difficult stooling fed hydrolyzed protein formula with added prebiotics: randomized controlled trial. Front Pediatr. 2022;10:894626.
- Kunz C, Lönnerdal B. Re-evaluation of the whey protein/casein ratio of human milk.