Enfamil® Optimum™ Gentlease®
Our closest ever gentle formula to breast milk. It is the only leading brand that has lactoferrin*, a component also found in breast milk and has our exclusive HuMO6 Premium Immune Blend† that has Dual HMOs (2'FL & LNnT).
Enfamil Optimum Gentlease is a 20 Cal/fl oz milk-based, iron-fortified infant formula designed to ease fussiness, gas and crying. Enfamil Optimum Gentlease is the trusted Gentlease formula, designed to reduce fussiness, gas and crying in 24 hours1. Enfamil Optimum Gentlease has lactoferrin* previously only largely available in breast milk to support immune health. It also has naturally occurring MFGM‡, a building block of the brain, as well as expert recommended, brain-building DHA and has a dual HMO blend of 2’-FL and LNnT to support immune and gut health.
*Added as an ingredient
†2’-FL & LNnT HMO (2’-Fucosyllactose & Lacto-N-neotetraose Human Milk Oligosaccharide. Not from human milk), Vit C & E, Selenium, Zinc
‡From whey protein concentrate
Designed to have easy-to-digest gentle partially hydrolyzed to support digestive comfort
- All-in-one gentle comfort for easing fussiness, crying, gas, and spit-up in 24 hours1*
- 80% reduced lactose compared to standard routine formulas
- Easy-to-digest 60:40 whey-to-casein ratio prior to partial hydrolyzation, patterned after mature breast milk†
- Safe and well-tolerated source of nutrition
Lactoferrin‡, an important immune-supporting protein also found in breast milk, has been shown to:
- Support respiratory and gut health2§
DHA has been demonstrated in clinical studies to:
- Support cognitive and visual development3-6||
- Promote cognitive outcomes through 5 years of age6||
Brain Building naturally occurring MFGM demonstrated in clinical studies to:
- Provide cognitive development similar to breastfed babies at 12 months of age7
- Increase neurodevelopmental scores at 12 months of age8¶
- Support cognitive, motor and communications skills through 5 years of age6,8,9#
A proprietary HuMO6♠ Premium Immune Blend that has 2’-FL and LNnT to support immune and gut health.
Additional product features:
- Non-GMO♥
- Kosher Dairy (OU-D), Halal
- Inositol also found in breast milk
*Based on the study of the prior Gentlease formulation without MFGM or prebiotics
†Comparison based on whey:casein ratio of typical mature breast milk (15 days to 6 months after birth).10
‡Added as an ingredient
§Based on infants who received a LF-supplemented formula between 4-6 months of age
||Studies compared infants fed Enfamil® that had DHA and ARA vs. discontinued Enfamil without DHA and ARA; studied before the addition of prebiotics.
¶As indicated by Bayley-III cognitive, language and motor scores at 12 months in a study of a different formula with MFGM and lactoferrin added as ingredients compared to a standard formula without.
#Cognitive skills as indicated by WPPSI-IV, tested at 5.5 to 6 years of age in a study of infant formula with MFGM. Communication skills as indicated by PPVT-III and WPPSI-III tested at 5 and 6 years of age respectively in a study of infant formula with DHA. Motor skills measured through 12 months of age.
♠2’-FL & LNnT HMO (2’-Fucosyllactose & Lacto-N-neotetraose Human Milk Oligosaccharide. Not from human milk), Vit C & E, Selenium, Zinc
♥Ingredients not genetically engineered. Trace amounts of genetically engineered material may be presented in the product, such as from manufacturing environments and process sources. For more information, visit enfamil.com/nonGMO↗.
Enfamil Optimum Gentlease is designed to have the sole source of nutrition for infants up to age 6 months and a major source of nutrition for the remainder of the first year.
Ingredients: Corn syrup solids, partially hydrolyzed nonfat milk and whey protein concentrate solids (soy)*, vegetable oil (contains one or more of the following: palm olein oil, coconut oil, soy oil, high oleic sunflower oil), and less than 2%: lacto-n-neotetraose†, 2'-fucosyllactose†, lactoferrin, mortierella alpina oil‡, schizochytrium sp. oil§, sodium citrate, calcium phosphate, potassium chloride, calcium carbonate, magnesium phosphate, ferrous sulfate, zinc sulfate, cupric sulfate, manganese sulfate, potassium iodide, sodium selenite, soy lecithin, choline chloride, inositol, ascorbic acid, niacinamide, calcium pantothenate, riboflavin, thiamin hydrochloride, vitamin D3, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin B12, vitamin E acetate, vitamin A palmitate, taurine, L-carnitine.
POTENTIAL ALLERGENS
Enfamil Optimum Gentlease contains milk and soy.
*A source of MFGM (Milk Fat Globule Membrane composed of proteins and fats) components.
†A source of HMO (2'-FL & LNnT Human Milk Oligosaccharides).
‡A source of arachidonic acid (ARA).
§A source of docosahexaenoic acid (DHA).
||Infrequent spit-up characterized as generally less than 5x per day.
¶Added as an ingredient.
Ingredient Transparency
Explore the function behind our ingredients.
Product nutrient values and ingredients are subject to change. Please see product label for current information.
| Nutrient Density | 20 Calories/fl oz |
|---|---|
| Protein (% Calories) | 9 |
| Whey:Casein Ratio | 60:40 |
| Fat (% Calories) | 48 |
| Carbohydrate (% Calories) | 43 |
| Potential Renal Solute Load (mOsm/100 Calories)8 | 21 |
| Potential Renal Solute Load (mOsm/100 mL)8 | 14.2 |
| Osmolality (mOsm/kg water) | 210 |
| Osmolarity (mOsm/L) | |
| Lactose-free | No |
| Galactose-Free | No |
| (Normal Dilution) | Per 100 Calories (5 fl oz) | Per 100 mL Powder | Per 100 grams Powder (510 Cal) |
|---|---|---|---|
| Protein, g | 2.3 | 1.56 | 11.7 |
| Fat, g | 5.3 | 3.6 | 27 |
| Linoleic acid, mg | 780 | 530 | 4000 |
| Carbohydrate, g | 10.9 | 7.4 | 56 |
| Water, g | 133 | 90 | 2.1 |
| Vitamins/Other Nutrients | |||
| Vitamin A, IU | 300 | 200 | 1530 |
| Vitamin D, IU | 70 | 47 | 360 |
| Vitamin E, IU | 2 | 1.35 | 10.2 |
| Vitamin K, mcg | 9 | 6.1 | 46 |
| Thiamin (Vitamin B1), mcg | 80 | 54 | 410 |
| Riboflavin (Vitamin B2), mcg | 140 | 95 | 710 |
| Vitamin B6, mcg | 60 | 41 | 310 |
| Vitamin B12, mcg | 0.3 | 0.2 | 1.53 |
| Niacin, mcg | 1000 | 680 | 5100 |
| Folic acid (Folacin), mcg | 16 | 10.8 | 82 |
| Pantothenic acid, mcg | 500 | 340 | 2600 |
| Biotin, mcg | 3 | 2 | 15.3 |
| Vitamin C (Ascorbic acid), mg | 12 | 8.1 | 61 |
| Choline, mg | 24 | 16.2 | 122 |
| Inositol, mg | 24 | 16.2 | 122 |
| Minerals | |||
| Calcium, mg | 82 | 55 | 420 |
| Phosphorus, mg | 46 | 31 | 230 |
| Magnesium, mg | 8 | 5.4 | 41 |
| Iron, mg | 1.8 | 1.22 | 9.2 |
| Zinc, mg | 1 | 0.68 | 5.1 |
| Manganese, mcg | 15 | 10.1 | 77 |
| Copper, mcg | 75 | 51 | 380 |
| Iodine, mcg | 15 | 10.1 | 77 |
| Selenium, mcg | 2.8 | 1.89 | 14.3 |
| Sodium, mg | 40 | 27 | 200 |
| Potassium, mg | 108 | 73 | 550 |
| Chloride, mg | 63 | 43 | 320 |
AMINO ACID COMPOSITION
Essential and Nonessential Amino Acids
DILUTION INFORMATION FOR ENFAMIL® OPTIMUM™ GENTLEASE®
Mixing instruction by the scoop
Download dilution information ↗
Mixing instruction by the quart
Download dilution information ↗
POWDER
Instructions for Preparation & Use:
A baby’s health depends on carefully following the instructions below. Use only as directed by a medical professional. Proper hygiene, preparation, dilution, use, and storage are important when preparing infant formula. Powdered infant formulas are not sterile and should NOT be fed to premature infants or infants who might have immune problems unless directed and supervised by a doctor.
Discuss with parents which formula is appropriate for the baby.
Discuss with parents whether they need to use cooled, boiled water for mixing and whether they need to boil clean utensils, bottles, and nipples in water before use.
WARNING: Do not use a microwave oven to warm formula. Serious burns may result.
Refer to the product label for the most accurate information.
Failure to follow these instructions could result in severe harm. Once prepared, infant formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use prepared formula if it is unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use formula within 1 hour or discard.
- Wash hands thoroughly with soap and water before preparing formula.
- Pour the desired amount of water into the bottle. Add powder.
- Cap bottle and SHAKE WELL.
Use the following chart for correct amounts of water and powder.
| To Make* | Water | Powder | Weight |
|---|---|---|---|
| 2 fl oz bottle | 2 fl oz | 1 unpacked level scoop | 8.7 g |
| 4 fl oz bottle | 4 fl oz | 2 unpacked level scoops | 17.4 g |
| 8 fl oz bottle | 8 fl oz | 4 unpacked level scoops | 34.8 g |
*Each scoop adds about 0.2 fl oz to the amount of prepared formula
| Calories Desired (Per fl oz‡) | Calories Desired (Per mL) | Add 1 Scoop Powder to Water (fl oz) | Formula Yield (fl oz) |
|---|---|---|---|
| 20 | 0.68 | 2 | 2.2 |
| 22 | 0.74 | 1.8 | 2 |
| 24 | 0.81 | 1.6 | 1.8 |
| 27 | 0.91 | 1.4 | 1.6 |
| 30 | 1.01 | 1.3 | 1.5 |
Enfamil Optimum Gentlease should be measured with unpacked, level scoops.
‡Fluid ounce measures in the above table are rounded to the nearest 0.1 fl oz
POWDER STORAGE
Tubs
Store powder at room temperature; avoid extreme temperatures. After opening, keep pouch and tub tightly closed, store in a dry area and use contents within 1 month. Use tub with formula indicated on label only.
Keep powder fresh and prevent bacterial growth by assuring tub is clean and completely dry. Completely empty tub and wipe clean with a clean, dry cloth before refilling.
When using refill pouches, remove the empty pouch and wipe tub with a clean, dry cloth.
Please new refill pouch inside the tub and keep the powder in the pouch.
Caution
- Always refer to the batch code and "use by" date on the refill pouch.
ENFAMIL OPTIMUM GENTLEASE IS AVAILABLE IN POWDER
Coding systems and reimbursement allowable rates vary by payer:
- Medicare Part B uses HCPCS (Healthcare Common Procedure Coding System) to group products
- Medicaid systems vary by state; some use HCPCS while others use NDC format code or systems of their own—contact your state provider for more information
- Private health insurance and managed care companies may use HCPCS, NDC format code or their own system—contact your provider for more information
Enfamil® Optimum™ Gentlease®, Powder (19.5 oz tub)
Item #: 172804
Description: Powder
Unit Size: 19.5 oz can
Calories/Unit: 2900
Product Yield/Unit (fl oz): 140
Case: 4 tubs per case
HCPCS Code: B4158**
NDC Format Code: 00087-5123-53
Clinical Study
Clinical Study
Improved Neurodevelopmental Outcomes at 5.5 Years of Age in Children Who Received Bovine Milk Fat Globule Membrane and Lactoferrin in Infant Formula Through 12 Months: A Randomized Controlled Trial
Clinical Monograph
NEW INSIGHTS INTO BIOACTIVE COMPONENTS OF HUMAN MILK: LACTOFERRIN
- Berseth CL, Johnston WH, Stolz Sl, et al. Clinical response to 2 commonly used switch formulas occurs within 1 day. Clin Pediatr (Phila). 2009;48:58-65.
- Chen K, Chia L, Li H, et al. Effect of bovine lactoferrin from iron-fortified formulas on diarrhea and respiratory tract infections of weaned infants in a randomized controlled trial. Nutrition. 2016;32:222-227.
- Birch EE, Hoffman DR, Uauy R, et al. Visual acuity and the essentiality of docosahexaenoic acid and arachidonic acid in the diet of term infants. Pediatr Res. 1998;44:201-209.
- Birch EE, Garfield S, Hoffman DR, et al. A randomized controlled trial of early dietary supply of long-chain polyunsaturated fatty acids and mental development in term infants. Dev Med Child Neurol. 2000;42:174-181.
- Morale SE, Hoffman DR, Castaneda YS, et al. Duration of long-chain polyunsaturated fatty acids availability in the diet and visual acuity. Early Hum Dev. 2005;81:197-203.
- Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation on childhood cognitive outcomes. Am J Clin Nutr. 2013;98:403-412.
- Timby N, Domellöf E, Hernell O, Lönnerdal B, Domellöf M. Neurodevelopment, nutrition, and growth until 12 mo of age in infants fed a low-energy, low-protein formula supplemented with bovine milk fat globule membranes: a randomized controlled trial. Am J Clin Nutr. 2014;99(4):860-868.
- Li F, Wu SS, Berseth CL, et al. Improved Neurodevelopmental Outcomes Associated with Bovine Milk Fat Globule Membrane and Lactoferrin in Infant Formula: A Randomized, Controlled Trial. J Pediatr. 2019;215:24-31.e8.
- Colombo J, Harris CL, Wampler JL, et al. Improved Neurodevelopmental Outcomes at 5.5 Years of Age in Children Who Received Bovine Milk Fat Globule Membrane and Lactoferrin in Infant Formula Through 12 Months: A Randomized Controlled Trial [published online ahead of print, 2023 May 14]. J Pediatr. 2023;261:113483. doi:10.1016/j.jpeds.2023.113483
- Kunz C, Lönnerdal B. Re-evaluation of the whey protein/casein ratio of human milk.