
Enfamil® Premature 24 Cal/fl oz HP
Milk-based infant formula with extra protein for premature or low birth weight infants who are not being breastfed
Enfamil Premature 24 Cal/fl oz High Protein (HP) is a milk-based infant formula specifically formulated to meet the unique nutritional needs of rapidly growing premature or low birth weight infants who do not receive human milk.* Protein is a major driver of lean mass growth and neuro-cognitive outcomes, and Enfamil Premature Nutrition supports these protein needs.
Enfamil Premature 24 Cal/fl oz HP is specifically formulated to meet the unique nutritional needs of rapidly growing premature or low birth weight infants
- 3.6 g of protein/100 Calories
- Protein to support catch-up growth and development1-3
- Fat blend is 40% medium-chain triglycerides (MCT) oil to promote fat absorption4,5
- Carbohydrate blend of 60% corn syrup solids (glucose polymers) and 40% lactose that is easily digested and helps avoid overloading the premature infant's capacity to digest lactose
- Provides approximately 2 mg iron/kg body weight when fed at 120 Cal/kg body weight per day
- 80:20 whey-to-casein ratio patterned after early human milk*
- DHA at 0.34% of total fatty acids, similar to the worldwide breast milk average‡6, to help support blood concentration of DHA as well as brain and eye development7
In a multi-center study, 64% of preterm infants had low vitamin D† concentrations at birth8
Enfamil Premature 24 Cal/fl oz HP has calcium, phosphorus and Vitamin D to help support bone mineralization and growth.
Additional product features:
- Kosher Dairy (OU-D), Halal
*Whey-to-casein ratio 3-5 days after lactation begins.
†Serum 25 (OH) D concentrations <50 nmol/L at birth.
‡Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women.7
When more than 12 fl oz (355 mL) of 24 Calories/fl oz product is used per day, which may occur in larger infants weighing over 2500 g (5.5 lbs) consuming only Enfamil Premature, intake of some nutrients (eg, fat soluble vitamins) may be excessive. In such circumstances, it should be used only at the direction and under the supervision of a doctor. Enfamil® NeuroPro EnfaCare® ↗ may be a product to consider in such circumstances.*
*Increased caloric density, protein, and some vitamins and minerals compared to standard term formula to help support weight and growth in babies born prematurely.
Ingredients: Ready to feed (2 fl oz Nursette bottles): Water, nonfat milk, corn syrup solids, whey protein concentrate, lactose, medium chain triglycerides (MCT oil), soy oil, high oleic sunflower oil and less than 0.5%: Mortierella alpina oil*, schizochytrium sp. oil†, calcium carbonate, calcium chloride, calcium hydroxide, calcium phosphate, cupric sulfate, ferrous sulfate, magnesium phosphate, potassium citrate, potassium iodide, sodium chloride, sodium citrate, sodium selenite, zinc sulfate, biotin, calcium pantothenate, folic acid, niacinamide, riboflavin, sodium ascorbate, thiamin hydrochloride, vitamin A palmitate, Vitamin B12, vitamin B6 hydrochloride, vitamin D3, vitamin E acetate, vitamin K1, rice starch, inositol, mono- and diglycerides, choline chloride, soy lecithin, nucleotides (cytidine 5’-monophosphate, adenosine 5’-monophosphate, disodium uridine 5’-monophosphate, disodium guanosine 5’-monophosphate, taurine, L-carnitine.
*A source of arachidonic acid (ARA).
†A source of docosahexaenoic acid (DHA).
ALLERGEN INFORMATION
Enfamil Premature 24 Cal/fl oz HP contains milk and soy.
| (Normal Dilution) | Per 100 Calories | Per 100 mL |
|---|---|---|
| Protein, g | 3.6 | 2.9 |
| Fat, g | 5 | 4.1 |
| Linoleic acid, mg | 810 | 660 |
| Carbohydrate, g | 10.5 | 8.5 |
| Water, g | 108 | 88 |
| Vitamins/Other Nutrients | ||
| Vitamin A, IU | 1350 | 1100 |
| Vitamin D, IU | 300 | 240 |
| Vitamin E, IU | 6.3 | 5.1 |
| Vitamin K, mcg | 9 | 7.3 |
| Thiamin (Vitamin B1), mcg | 200 | 162 |
| Riboflavin (Vitamin B2), mcg | 300 | 240 |
| Vitamin B6, mcg | 150 | 122 |
| Vitamin B12, mcg | 0.25 | 0.2 |
| Niacin, mcg | 4000 | 3200 |
| Folic acid (Folacin), mcg | 40 | 32 |
| Pantothenic acid, mcg | 1200 | 970 |
| Biotin, mcg | 4 | 3.2 |
| Vitamin C (Ascorbic acid), mg | 20 | 16.2 |
| Choline, mg | 30 | 24 |
| Inositol, mg | 44 | 36 |
| Minerals | ||
| Calcium, mg | 165 | 134 |
| Phosphorus, mg | 90 | 73 |
| Magnesium, mg | 9 | 7.3 |
| Iron, mg | 1.8 | 1.46 |
| Zinc, mg | 1.8 | 1.46 |
| Manganese, mcg | 6.3 | 5.1 |
| Copper, mcg | 120 | 97 |
| Iodine, mcg | 25 | 20 |
| Selenium, mcg | 6.4 | 5.2 |
| Sodium, mg | 70 | 57 |
| Potassium, mg | 98 | 80 |
| Chloride, mg | 106 | 86 |
Product nutrient values and ingredients are subject to change. Please see product label for current information.
| Nutrient Density | 24 Calories/fl oz |
|---|---|
| Protein (% Calories) | 14 |
| Whey:Casein Ratio | 80:20 |
| Fat (% Calories) | 44 |
| Carbohydrate (% Calories) | 42 |
| Potential Renal Solute Load (mOsm/100 Calories)9 | 32 |
| Potential Renal Solute Load (mOsm/100 mL)9 | 26 |
| Osmolality (mOsm/kg water) | 300 |
| Osmolarity (mOsm/L) | 260 |
| Lactose-free | No |
AMINO ACID COMPOSITION
Essential and Nonessential Amino Acids
FEEDING INFORMATION FOR ENFAMIL PREMATURE 24 Cal/fl oz HP
Guidelines alternate feeding needs
Download dilution information ↗
NURSETTE® BOTTLES
A baby’s health depends on carefully following the instructions below. Use only as directed by a medical professional. Proper hygiene, preparation, dilution, use and storage are important when preparing infant formula.
2 fl oz Bottles
Inspect each bottle for signs of damage.Wash hands thoroughly with soap and water before preparing bottle for feeding.SHAKE BOTTLE WELL and remove cap. Attach nipple unit (not included).
Failure to follow these instructions could result in severe harm. Open bottles can spoil quickly. Either feed immediately or replace cap and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use prepared formula if it is unrefrigerated for more than a total of 2 hours. Do not freeze opened bottle. After feeding begins, use formula within 1 hour or discard.
Warning: Do not use a microwave oven to warm formula. Serious burns may result.
Storage: Store unopened bottles at room temperature. Avoid excessive heat and prolonged exposure to light. Do not freeze.
THIS PRODUCT SHOULD BE USED ONLY AS DIRECTED BY THE BABY’S DOCTOR.
USE BY DATE ON CARTON AND BOTTLE LABEL.
DO NOT USE IF CAP RING IS BROKEN OR MISSING.
DO NOT ACCEPT IF PACKAGE HAS BEEN OPENED.
ENFAMIL® PREMATURE 24 Cal/fl oz HP IS AVAILABLE IN READY-TO-USE NURSETTE® BOTTLES
When using this information, please note the following:
Coding systems and reimbursement allowable rates vary by payer:
- Medicare Part B uses HCPCS (Healthcare Common Procedure Coding System) to group products
- Medicaid systems vary by state; some use HCPCS while others use NDC format code or systems of their own—contact your state provider for more information
- Private health insurance and managed care companies may use HCPCS, NDC format code or their own system—contact your provider for more information

Enfamil® Premature 24 Cal/fl oz HP, Ready-to-Feed (2 fl oz Nursette® bottle)
Item #: 461001
Description: RTF, 24 Cal/fl oz
Unit Size: 2 fl oz bottle
Calories/Unit: 48
Product Yield/Unit (fl oz): 2
Case: 48 bottles per case
HCPCS Code: B4160
NDC Format Code: 00087-5115-74
- Koletzko B, Cheah F-C, Domellof M, Poindexter BB, Vain N, van Goudoever JB (eds): Nutritional Care of Preterm Infants. Scientific Basis and Practical Guidelines. World Rev Nutr Diet. Basel, Karger, 2021, vol 122.
- Klein CJ. Nutrient requirements for preterm infant formulas. J Nutr. 2002;132 (6 suppl 1):1395S-1577S.
- Agostoni C, Buonocore G, Carnielli VP, et al. Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2010;50(1):85-91.
- Tantibhedhyangkul P, Hashim SA. Medium-chain triglyceride feeding in premature infants: effects on fat and nitrogen absorption. 1975;55:359-370.
- Andrews BF, Lorch V. Improved fat and Ca absorption in LBW infants fed a medium-chain triglyceride containing formula [abstract]. Pediatr Res. 1974;8:104.
- Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464.
- Innis SM, Adamkin DH, Hall RT, et al. Docosahexaenoic acid and arachidonic acid enhance growth with no adverse effects in preterm infants fed formula. J Pediatr. 2002;140:547-554.
- Monangi N, et al. Vitamin D status of early preterm infants and the effects of vitamin D intake during hospital stay. Arch Dis Child Fetal Neonatal Ed. 2014;99:F166-F168.
- Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14.