Products

    Enfamil® Enspire™

    Milk-based infant formula with MFGM to foster cognitive development and lactoferrin to support immune health.

    Indication

    Enfamil Enspire is a 20 Cal/fl oz milk-based, iron-fortified, routine formula for full-term infants 0–12 months. Enfamil Enspire has two components previously only largely available in breast milk: MFGM to foster cognitive development and lactoferrin to support immune health.

    Ingredients

    Ingredients: Ingredients: Nonfat milk, lactose, vegetable oil (palm olein, coconut, soy and high oleic sunflower oils), whey protein-lipid concentrate* (milk), whey protein concentrate and less than 2%: lactoferrin, galactooligosaccharides, polydextroseMortierella alpina oilCrypthecodinium cohnii oil§, potassium citrate, calcium carbonate, calcium phosphate, sodium chloride, potassium chloride, ferrous sulfate, magnesium oxide, zinc sulfate, cupric sulfate, manganese sulfate, potassium iodide, sodium selenite, soy lecithin, choline chloride, ascorbic acid, niacinamide, calcium pantothenate, riboflavin, thiamin hydrochloride, vitamin D3, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin B12, inositol, vitamin E acetate, vitamin A palmitate, nucleotides (cytidine 5’-monophosphate, disodium uridine 5’-monophosphate, adenosine 5’-monophosphate, disodium guanosine 5’-monophosphate), taurine, L-carnitine.

    *A source of MFGM (milk fat globule membrane).
    †A type of prebiotic.
    ‡A source of arachidonic acid (ARA).
    §A source of docosahexaenoic acid (DHA).

    POTENTIAL ALLERGENS

    Enfamil Enspire contains milk and soy.

    Nutrients

    (Normal Dilution)

    Per 100 Calories (5 fl oz)

    Per 100 mL

    Per 100 grams Powder (500 Cal)

    Protein, g

    2.1

    1.42

    10.5

    Fat, g

    5.3

    3.6

    27

    Linoleic acid, mg

    800

    540

    4000

    Carbohydrate, g

    11.2

    7.6

    56

    Water, g

    133

    90

    2.8

    Vitamins/Other Nutrients

         

    Vitamin A, IU

    300

    200

    1500

    Vitamin D, IU

    60

    41

    300

    Vitamin E, IU

    2

    1.35

    10

    Vitamin K, mcg

    9

    6.1

    45

    Thiamin (Vitamin B1), mcg

    80

    54

    400

    Riboflavin (Vitamin B2), mcg

    140

    95

    700

    Vitamin B6, mcg

    60

    41

    300

    Vitamin B12, mcg

    0.3

    0.2

    1.5

    Niacin, mcg

    1000

    680

    5000

    Folic acid (Folacin), mcg

    16

    10.8

    80

    Pantothenic acid, mcg

    500

    340

    2500

    Biotin, mcg

    3

    2

    15

    Vitamin C (Ascorbic acid), mg

    12

    8.1

    60

    Choline, mg

    24

    16.2

    120

    Inositol, mg

    6

    4.1

    30

    Minerals

         

    Calcium, mg

    78

    53

    390

    Phosphorus, mg

    43

    29

    220

    Magnesium, mg

    8

    5.4

    40

    Iron, mg

    1.8

    1.22

    9

    Zinc, mg

    1

    0.68

    5

    Manganese, mcg

    15

    10.1

    75

    Copper, mcg

    75

    51

    380

    Iodine, mcg

    15

    10.1

    75

    Selenium, mcg

    2.8

    1.89

    14

    Sodium, mg

    27

    18.3

    135

    Potassium, mg

    108

    73

    540

    Chloride, mg

    63

    43

    320

    Product nutrient values and ingredients are subject to change. Please see product label for current information.

    Nutrient Density

    20 Calories/fl oz

    Protein (% Calories)

    8.5

    Whey:Casein Ratio

    60:40

    Fat (% Calories)

    48

    Carbohydrate (% Calories)

    43.5

    Potential Renal Solute Load (mOsm/100 Calories)10

    19.1

    Potential Renal Solute Load (mOsm/100 mL)10

    12.9

    Osmolality (mOsm/kg water)

    300

    Osmolarity (mOsm/L)

    270

    Lactose-free

    No

    AMINO ACID COMPOSITION

    ESSENTIAL AMINO ACIDS

    mg/100 Cal

    mg/100 mL*

    Arginine

    78

    53

    Histidine

    55

    37

    Isoleucine

    111

    75

    Leucine

    220

    151

    Methionine

    46

    31

    Cysteine

    38

    26

    Phenylalanine

    95

    64

    Proline

    164

    111

    Threonine

    122

    82

    Tryptophan

    34

    23

    Valine

    126

    85

    *At 20 Cal/fl oz.

    Source of protein: 50% nonfat milk, 31% Whey protein-lipid concentrate (Source of MFGM), 14.3% Whey protein concentrate, 4.3% Lactoferrin.

    Product Forms and Ordering Information

    ENFAMIL PREMIUM NEWBORN IS AVAILABLE IN POWDER

    Coding systems and reimbursement allowable rates vary by payer:

    • Medicare Part B uses HCPCS (Healthcare Common Procedure Coding System) to group products
    • Medicaid systems vary by state; some use HCPCS while others use NDC format code or systems of their own—contact your state provider for more information
    • Private health insurance and managed care companies may use HCPCS, NDC format code or their own system—contact your provider for more information

     

      Enfamil® Enspire, Powder
      Item #: 157401
      Description: Powder
      Unit Size: 20.5 oz tub
      Calories/Unit: 2940
      Product Yield/Unit (fl oz): 147
      Case: 4 tubs per case
      HCPCS Code: B4158
      NDC Format Code: 00087-5117-48

    PRODUCT BENEFITS

    Enfamil Enspire brings formula closer to breast milk than ever before

    • Milk fat globule membrane (MFGM) provides the brain-building advantages of breast milk and is shown to improve cognitive outcomes at 12 months1
    • Lactoferrin supports immune health and brings Enfamil® composition closer to human milk than ever before2
    • Easy-to-digest 60:40 whey-to-casein ration, patterned after mature breast milk*3

    Proprietary Triple Health Guard® blend of brain-nourishing DHA, an exclusive dual prebiotic blend, and 30 total nutrients for growth

    DHA at the clinically proven amount of 0.32% of total fatty acids, the same amount as the worldwide breast milk average,‡4 and double the amount found in the leading competitor’s product§

    • Clinically proven to support mental, visual and immune system development
    • Clinically shown to improve long-term cognitive outcomes through 5 years of age†5
    • Shown to improve respiratory health through the first 3 years of life when infants were fed through 12 months†6

    Exclusive Natural Defense® Dual Prebiotic blend to support immune and digestive health

    • Proprietary blend of GOS (galactooligosaccharides) and PDX (polydextrose)
    • Clinically proven at 4 g/L to support immune health by promoting the growth of beneficial bacteria (bifidobacteria and lactobacilli)7,8
    • Promotes soft stools similar to those reported for breastfed infants9

    Additional product features:

    • Non-GMO||
    • Kosher

    *Comparison based on whey-to-casein of typical mature breast milk (15 days to 6 months after birth).

    †Studies compared infants fed Enfamil® with DHA and ARA vs. discontinued Enfamil without DHA and ARA; studied before the addition of prebiotics.
    ‡Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women.4
    §Enfamil Enspire has not been shown superior to the leading competitor in supporting mental, visual and immune system development. The level of DHA in Similac Pro-Advance is ~0.15% of total fatty acids.
    || Ingredients not genetically engineered. Trace amounts of genetically engineered material may be present in the product, such as from manufacturing environments and process sources. For more information, visit enfamil.com/nonGMO.

    Layout:
    Enfamil NeuroPro™ Infant
    Learn about another routine formula option with MFGM.
    Enfamil® Enspire™ Gentlease®
    Enfamil® Enspire™ also has an option for fussy, gassy babies.
    Contact Mead Johnson
    Contact a Mead Johnson representative to request information and samples.

    References

    1. Timby N, Domellöf E, Hernell O, et al. Neurodevelopment, nutrition, and growth until 12 mo of age in infants fed a low-energy, low-protein formula supplemented with bovine milk fat globule membranes: a randomized controlled trial. Am J Clin Nutr.2014;99:860-868.
    2. King JC Jr, Cummings GE, Guo N, et al. A double-blind, placebo-controlled, pilot study of bovine lactoferrin supplementation in bottle-fed infants. J Pediatr Gastroenterol Nutr.2007;44:245-251.
    3. Kunz C, Lönnerdal B. Re-evaluation of the whey protein/casein ratio of human milk. Acta Paediatr. 1992;81:107-112.
    4. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr.2007;85:1457-1464.
    5. Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation on childhood cognitive outcomes. Am J Clin Nutr.2013;98:403-412.
    6. Birch EE, Khoury JC, Berseth CL, et al. The impact of early nutrition on incidence of allergic manifestations and common respiratory illnesses in children. J Pediatr.2010;156:902-906.
    7. Scalabrin D, Mitmesser SH, Welling GW, et al. New prebiotic blend of polydextrose and galacto-oligosaccharides has a bifidogenic effect in young infants. J Pediatr Gastroenterol Nutr. 2012;54:343-352.
    8. Salminen S, Endo A, Isolauri E, et al. Early gut colonization with lactobacilli and staphylococcus in infants: the hygiene hypothesis extended. J Pediatr Gastroenterol Nutr.2016;62:80-86.
    9. Ziegler E, Vanderhoof JA, Petschow B et al. Term infants fed formula supplemented with selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. J Pediatr Gastroenterol Nutr.2007;44:359-364.
    10. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14